The 2008 Honda Accord's superior safety performance has received 5-star frontal crash safety rating from the National Traffic Safety Association (NHTSA) for both driver and front passenger. NHTSA is a U.S. Government agency, part of the Department of Transportation, responsible for setting safety standards and verifying compliance by automobile manufacturers. NHTSA utilizes crash-rating dummies, representing an average sized adult, to identify impact on passengers during frontal collision. Frontal star ratings indicate the likelihood of a serious head and chest injury to the driver and front passenger. Five-star rating, the highest rating possible, represents 10% or less chance of serious injury.

The All-New Accord has also earned the 2008 "Top Safety Pick" by the Insurance Institute for Highway Safety (IIHS), a U.S. independent, non-profit, research and communications organization dedicated to reducing highway crash injuries, deaths and property damages. The award was a result of IIHS' extensive tests including frontal, side and rear crash test evaluations.

One of Honda's core thrusts includes comprehensive methodology to vehicle safety. Through its 'Safety for Everyone' approach, Honda consistently develops technologies that provide high level of protection for both passengers and pedestrian. Every Accord is equipped with an Advanced Compatibility Engineering (ACE) Body Structure that enhances energy dispersion during frontal collision through a network of load bearing structures. It also comes with newly-designed side-curtain airbags, driver's and front passenger's dual-chamber side airbags with a passenger-side Occupant Position Detection System (OPDS). Standard safety features include Vehicle Stability Assist (VSA) system, a 4-wheel disc Anti-lock Brake System (ABS) with brake assist and Eletronic Brake Distribution (EBD).

In developing and enhancing safety designs and technologies, Honda operates two of the most advanced crash test laboratories in the world. The development center in Tochigi, Japan houses state-of-the-art research equipment such as indoor car-to-car crash testing facility. Honda R&D America's center in Raymond, Ohio performs advanced testing on all U.S. developed models. It allows speedy crash-test simulations with certain safety components like seats and seatbelts before conducting a crash test with an actual vehicle. Its facility also enables accurate measurement of the distribution of load impact on the vehicle. These two laboratories aid Honda in creating advanced vehicle designs for occupant and pedestrian safety.